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Dynamic changes of high-sensitivity troponin T concentration during infancy: Clinical implications

P Jehlicka1, D Rajdl, E Sladkova

  • 1Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic. jehlicka@fnplzen.cz.

Physiological Research
|January 17, 2021
PubMed

Insights

High-sensitive cardiac troponin T (hscTnT) levels are significantly higher in infants than adults. Age-related reference intervals are crucial for accurate interpretation in pediatric cardiology, with levels approaching adult values around one year of age.

Area of Science:

  • Pediatric Cardiology
  • Biomarker Analysis
  • Clinical Diagnostics

Background:

  • Cardiac troponin T (cTnT) is vital for diagnosing heart conditions.
  • Current high-sensitive cTnT (hscTnT) assays have established adult cut-offs, but pediatric reference values remain unclear.
  • Accurate interpretation of hscTnT in infants is essential for appropriate clinical decision-making.

Purpose of the Study:

  • To determine plasmatic concentrations of hscTnT in healthy infants and toddlers.
  • To describe age-related dynamic changes in hscTnT levels.
  • To establish age-specific reference intervals for hscTnT in this population.

Main Methods:

  • Prospective observational study involving 78 healthy children (44-872 days old).
  • Plasma hscTnT concentrations analyzed using an electrochemiluminescent method.
  • Age-related reference intervals calculated via polynomial regression, with the 99th percentile determined.

Main Results:

  • A significant negative correlation between hscTnT concentration and age (r=-0.81, p<0.001) was observed.
  • The 99th percentile for hscTnT decreased with age, reaching adult levels (14 ng/l) around 1 year.
  • No significant gender differences in hscTnT levels were found (p>0.07).

Conclusions:

  • Infant hscTnT reference intervals are substantially higher than those in adults.
  • Age-specific interpretation of hscTnT is recommended for infants and toddlers.
  • These findings aid in the accurate diagnosis of myocardial pathologies in young children.

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