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3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression.

Pravin Shende1, Riddhi Trivedi2

  • 1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India. shendepravin94@gmail.com.

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3D bioprinting enables precise layer-by-layer deposition for creating biological structures and scaffolds. This technology is advancing gene therapy, editing, and delivery, offering new treatment possibilities.

Keywords:
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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Additive manufacturing, specifically 3D bioprinting, provides biocompatible methods for producing biological structures and scaffolds.
  • Computer-assisted 3D bioprinting facilitates the development of nano/micro-particulate systems for various applications, including biosensors and drug delivery.
  • 3D bioprinting is increasingly explored for its potential in gene therapy, gene editing, and gene delivery systems.

Purpose of the Study:

  • This review focuses on the application of 3D bioprinting techniques in gene expression, gene editing, and gene delivery.
  • To explore the integration of nanotechnology with 3D bioprinting for enhanced gene delivery strategies.
  • To highlight the potential of 3D bioprinting in overcoming limitations of conventional gene therapy methods.

Main Methods:

  • Review of current literature on 3D bioprinting applications in genetic engineering and therapy.
  • Analysis of studies incorporating nanotechnology with 3D bioprinting for gene delivery.
  • Examination of 3D bioprinting's role in tissue engineering and regenerative medicine applications related to gene therapy.

Main Results:

  • 3D bioprinting facilitates precise control over the placement of cells and biomaterials for creating complex biological structures.
  • The integration of nanotechnology with 3D bioprinting enables the development of novel gene-conjugated or gene-encapsulated nanostructures.
  • Applications span gene therapy for cancers, tissue engineering, osteogenesis, and skin/vascular regeneration.

Conclusions:

  • 3D bioprinting offers a versatile platform for advancing gene therapy, editing, and delivery.
  • Nanotechnology integration with 3D bioprinting presents promising avenues for efficient and controlled genetic treatments.
  • The technology holds potential for real-time delivery and in-situ production of nucleic acids, overcoming conventional method limitations.