Related Experiment Video
Updated: Jul 19, 2026
06:31
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
8.9K
Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000-2016
J I Silverberg1,2, E M Warshaw3,4,5, H I Maibach6
1Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
The British Journal of Dermatology
|January 17, 2021
Summary
Pediatric hand eczema (HE) has distinct allergens, with nickel and methylisothiazolinone being common. Patch testing reveals similar positive rates in children with and without HE.
Area of Science:
- Dermatology
- Allergology
- Pediatrics
Background:
- Etiologies and relevant allergens for pediatric hand eczema (HE) are not well understood.
- Characterizing these factors is crucial for effective diagnosis and management in children.
Purpose of the Study:
- To identify the causes and common allergens in children and adolescents under 18 with hand eczema.
- To determine the prevalence of positive and currently relevant allergens in this pediatric population.
Main Methods:
- Retrospective analysis of North American Contact Dermatitis Group data from 2000-2016.
- Inclusion of 1634 pediatric patients, with a focus on the 237 diagnosed with hand eczema.
- Utilized multivariable logistic regression to identify associations and relevant allergens.
Main Results:
- Allergic contact dermatitis (49.4%), atopic dermatitis (37.1%), and irritant contact dermatitis (16.9%) were key diagnoses in pediatric HE.
- Children with HE showed similar positive patch test rates (56.1%) compared to those without (61.7%).
- Top relevant allergens included nickel, methylisothiazolinone, propylene glycol, decyl glucoside, and lanolin, with HE associated with specific allergens like lanolin and quaternium-15.
Conclusions:
- Pediatric patients with hand eczema referred for patch testing exhibit a high rate of positive results, comparable to controls.
- A distinct, relatively narrow profile of currently relevant allergens was identified in children with hand eczema.
