Effect of transurethral partial cystectomy with 2.0 μm laser in treating superficial bladder cancer

To compare and analyze the efficacy and safety of transurethral partial cystectomy with 2.0 μm laser and transurethral resection of bladder tumor (TURBT) in treating patients with superficial bladder cancer.

The clinical data of 130 patients with superficial bladder cancer were divided into two groups based on different treatments, with 65 patients in each group, and treated with transurethral partial cystectomy with 2.0 μm laser and TURBT separately. Then, operation conditions such as intraoperative blood loss, operation time, in-dwelling time of urinary catheter and length of hospital stay were recorded and compared between the two groups. Finally, the tumor recurrence in the patients was followed up and recorded.

The operation time (p<0.001) and length of hospital stay (p=0.013) were remarkably shorter, and the intraoperative blood loss (p<0.001) was notably smaller in laser group than those in TURBT group. Laser group had an evidently lower total incidence rate of complications than TURBT group (p=0.005). The patients were reexamined by cystoscopy at 4 weeks after operation, and the biopsy results indicated that there were markedly more cases of positive findings in TURBT groupthan those in laser group (no positive findings) (p=0.033). However, laser group exhibited distinctly decreased postoperative levels of IL-6 and TNF-α but an obviously increased IL-10 level compared with TURBT group (p<0.001). Besides, after 6-40 months of follow-up for all the patients, the total recurrence rate was prominently lower in laser group than that in TURBT group (p=0.006).

In contrast with TURBT, transurethral partial cystectomy with 2.0 μm laser for superficial bladder cancer can significantly reduce the operation time and intraoperative blood loss, improve the operative effect, induce fewer postoperative complications and cause milder body injury and inflammatory response at the same time, which is worthy of clinical promotion.