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Updated: Nov 21, 2025

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Polylactide-Based Chiral Porous Monolithic Materials Prepared Using the High Internal Phase Emulsion Template Method

Xueyong Yong, Qisong Hu, Ergang Zhou

    ACS Biomaterials Science & Engineering
    |January 18, 2021
    PubMed
    Summary

    Chiral porous poly(high internal-phase emulsion)s (polyHIPEs) derived from poly(l-lactide) (PLLA) show enantioselective drug release, unlike PDLA counterparts. Chirality significantly impacts polyHIPEs

    Keywords:
    biocompatibilitychiralityenantioselective releasepolylactideporous materials

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    Area of Science:

    • Polymer Chemistry
    • Materials Science
    • Biomaterials Engineering

    Background:

    • Polylactide (PLA) is a widely used biomaterial due to its biocompatibility, biodegradability, and mechanical properties.
    • The exploration of PLA's chirality in biomaterial applications remains limited.
    • Chiral porous poly(high internal-phase emulsion)s (polyHIPEs) offer a novel platform for investigating chiral properties.

    Purpose of the Study:

    • To prepare chiral polyHIPEs from enantiopure polylactides (PLLA and PDLA).
    • To investigate the enantioselective drug-loading and release capabilities of these chiral polyHIPEs.
    • To evaluate the biocompatibility and cellular effects of chiral polyHIPEs.

    Main Methods:

    • Preparation of chiral polyHIPEs using a high internal-phase emulsion (HIPE) template method with enantiopure PLLA and PDLA.
    • Assessment of optical activity of the synthesized polyHIPEs.
    • Evaluation of enantioselective drug loading and release using model chiral drugs (cinchona alkaloid and naproxen).
    • Cytotoxicity testing of PLLA-, PDLA-, and PDLLA-based polyHIPEs on cells.

    Main Results:

    • Chiral polyHIPEs with optical activity were successfully synthesized.
    • PLLA-based polyHIPEs exhibited enantioselectivity in both drug loading and release.
    • PDLA-based polyHIPEs did not show significant enantioselectivity.
    • All tested polyHIPEs demonstrated biocompatibility, but varying effects on cell growth were observed based on chirality.

    Conclusions:

    • Chiral polyHIPEs derived from enantiopure PLAs can be fabricated.
    • PLLA-based polyHIPEs show promise for enantioselective drug delivery applications.
    • The chirality of PLA significantly influences the performance and biological effects of polyHIPEs.
    • Further attention to PLA chirality is crucial for advanced biomaterial development.