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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Multistimuli-Responsive Polymeric Vesicles for Accelerated Drug Release in Chemo-photothermal Therapy
Yu Zhang1, Saji Uthaman2, Wenliang Song1
1BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Republic of Korea.
ACS Biomaterials Science & Engineering
|January 18, 2021
Summary
This study developed smart nanomedicines for cancer therapy, combining chemotherapy and photothermal treatment. These nanomedicines effectively deliver drugs and respond to stimuli for targeted cancer cell destruction.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Multistimuli-responsive nanomedicines offer on-demand drug release for enhanced cancer treatment.
- Developing smart carriers is crucial for selective and effective cancer therapies.
Purpose of the Study:
- To prepare a multifunctional polymeric vesicular nanocarrier (PVN) for combined chemo-photothermal therapy.
- To evaluate the stimuli-responsive drug release and therapeutic efficacy of the PVNs.
Main Methods:
- Fabrication of triple stimuli-responsive micelles forming PVNs.
- Encapsulation of doxorubicin (DOX) and IR780 iodide.
- In vitro assessment of drug release kinetics and photothermal cytotoxicity.
- Intracellular uptake studies in CT-26 cancer cells.
Main Results:
- PVNs exhibited stable size (∼100 nm) with high drug and photothermal agent loading (26.5 wt % DOX, 16.4 wt % IR780).
- Controlled DOX release was observed upon costimulation with endogenous stimuli.
- Laser irradiation induced significant photothermal cytotoxicity in CT-26 cells.
- PVNs were readily internalized by CT-26 cells, releasing DOX in the cytoplasm upon laser stimulation.
Conclusions:
- The developed PVNs are effective carriers for combined chemo-photothermal cancer therapy.
- The stimuli-responsive nature of PVNs enables targeted drug delivery and enhanced therapeutic outcomes.
- These nanomedicines show promise for developing advanced cancer treatment strategies.
Keywords:
NIR imagingantitumor immunitychemo-photothermal therapypolymeric nanoparticlesstimuli-responsiveMore Related Videos
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