Controlled Hydration, Transition, and Drug Release Realized by Adjusting Layer Thickness in...

The controlled hydration, transition, and drug release are realized by adjusting layer thickness in thermoresponsive interpenetrating polymeric network (IPN) hydrogels on cotton fabrics. IPN hydrogels are synthesized by sodium alginate (SA) and poly(N-isopropylacrylamide) (PNIPAM) with a ratio of 1:5/% (w/v). The cotton-fabric-supported IPN hydrogels with a thickness of 1000 μm exhibit a transition temperature (TT) at 35.2 °C. When the hydrogel thicknesses are thinned to 500 and 250 μm, the TTs are reduced to 34.8 and 34.1 °C, respectively. Interestingly, the morphology of IPN hydrogels switches from a well-defined honeycomb-like network structure (1000 μm) to a densely packed layer structure (250 μm). The thinner layers not only present a smaller extent of hydration and collapse but also require longer time to reach an equilibrium state, which can be attributed to the more pronounced hindrance of the chain rearrangement by the cotton fabrics. To address the influence of layer thickness on the drug release, we compare the release rate and cumulative release percentage of the test drugs tetracycline hydrochloride (TCH) and levofloxacin hydrochloride (LH) between pure IPN hydrogels and cotton-fabric-supported IPN hydrogels (250, 500, and 1000 μm) at 25 °C (below the TT) and 37 °C (above the TT). Because of the compressive stress from the collapsed hydrogels, a higher release is observed in both hydrogels when the temperature is above TT. The cotton fabric induces a slower and less prominent drug release in IPN hydrogels. Thus, combining the obtained correlation between the transition and hydrogels layer thickness, the drug release in cotton-fabric-supported IPN hydrogels can be regulated by the layer thickness, which appears especially suitable for a controlled release in wound dressing applications.