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Regenerating Antithrombotic Surfaces through Nucleic Acid Displacement.

Stephanie L McNamara1,2,3, Yevgeny Brudno4,3, Alex B Miller2

  • 1John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, Massachusetts 02138, United States.

ACS Biomaterials Science & Engineering
|January 18, 2021
PubMed
Summary

This study introduces a regenerative antithrombotic (anti-clotting) catheter surface using oligodeoxynucleotide (ODN) toehold exchange. This novel method continuously replenishes anti-clotting agents, enhancing device longevity.

Keywords:
antithromboticblood-contacting devicesoligonucleotidesrefillable surface coatingstoehold exchange

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Area of Science:

  • Biomaterials Science
  • Biotechnology
  • Medical Devices

Background:

  • Blood-contacting devices require antithrombotic coatings to prevent clot formation and ensure longevity.
  • Current surface treatments degrade in vivo, limiting device efficacy and lifespan.

Purpose of the Study:

  • To develop a regenerative antithrombotic surface treatment for blood-contacting devices.
  • To utilize oligodeoxynucleotide (ODN) toehold exchange for sustained antithrombotic activity.

Main Methods:

  • Engineered ODN strands with antithrombotic payloads were immobilized on a surface.
  • ODN toehold exchange mechanism was employed for payload regeneration.
  • Thrombin inhibition and fibrin formation were assessed to evaluate antithrombotic efficacy.

Main Results:

  • Surface-bound ODNs effectively inhibited thrombin activity, reducing fibrinogen cleavage and fibrin formation.
  • The antithrombotic effect was sustained through multiple cycles of ODN exchange with fresh payloads.
  • The regenerative strategy demonstrated potential for long-term device performance.

Conclusions:

  • A novel regenerative antithrombotic surface treatment using ODN toehold exchange was successfully developed.
  • This approach offers a continuous antithrombotic state, overcoming limitations of current treatments.
  • The technology holds promise for improving the safety and efficacy of blood-contacting medical devices.