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Recurrent spontaneous coronary artery dissection

Susan N Kok1, Marysia S Tweet2

  • 1Division of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Expert Review of Cardiovascular Therapy
|January 18, 2021
PubMed

Insights

Spontaneous coronary artery dissection (SCAD) can recur in 5-29% of patients, posing significant cardiac risks. Further research is needed to identify risk factors and effective interventions for SCAD recurrence.

Area of Science:

  • Cardiology
  • Vascular Medicine

Background:

  • Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of acute coronary syndrome and sudden cardiac death, primarily affecting young to middle-aged women.
  • SCAD presents acute challenges including arrhythmias, heart failure, and chest pain, with a notable recurrence rate of 5-29%.

Purpose of the Study:

  • To provide an updated review of Spontaneous Coronary Artery Dissection (SCAD), with a specific focus on the risk factors and implications of SCAD recurrence.
  • To summarize current knowledge on SCAD-associated conditions, genetic factors, clinical characteristics, and post-SCAD care.

Main Methods:

  • A comprehensive literature search of PubMed articles was conducted up to October 2020.
  • The review focused on clinical studies and original research, scrutinizing findings related to SCAD recurrence.

Main Results:

  • SCAD recurrence represents a significant cardiac risk and psychological burden for patients.
  • Hypertension and severe coronary tortuosity are potential risk factors associated with SCAD recurrence.

Conclusions:

  • SCAD recurrence is a concerning risk that requires further investigation.
  • Additional research is essential to fully understand SCAD recurrence risk factors and to clarify the efficacy of interventions like beta-blocker therapy in reducing recurrence.

Keywords:
Myocardial infarctioncardiovascular diseasenon-atherosclerotic coronary artery diseaserecurrencespontaneous coronary artery dissectionwomen

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