Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

P2Y12 Inhibitors and Mortality in Patients Hospitalized With Intracerebral Hemorrhage.

JAMA network open·2026

Same author

Broussonin A Attenuates Type 2 Diabetic Osteoporosis by Reactivating JAK2/STAT3 Signaling to Inhibit Ferroptosis in BMSCs.

Phytotherapy research : PTR·2026

Same author

BCAA metabolism promotes lung cancer tumorigenesis by enhancing cholesterol biosynthesis.

Cell reports·2026

Same author

RstAB activates type 1 fimbriae to promote uropathogenic <i>Escherichia coli</i> bladder invasion.

iScience·2026

Same author

Mechanism Through Which Antioxidant Polysaccharide from <i>Tetrastigma hemsleyanum</i> Protects Against DSS-Induced Ulcerative Colitis: Insights from Multi-Omics.

Molecules (Basel, Switzerland)·2026

Same author

The evolution of liver graft preservation strategies in liver transplantation.

Hepatobiliary surgery and nutrition·2026

Search research articles

Related Experiment Video

Updated: Nov 21, 2025

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

A Sensitive Thrombin Aptasensor Based on Target Circulation Strategy.

Chen Jin¹, Mengqing Cheng¹, Guobing Wei¹

¹The Affiliated Hospital, Department of Pharmacy, JiangXi University of Traditional Chinese Medicine, JiangXi, 330004, China.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|January 18, 2021

Summary

This summary is machine-generated.

This study presents a novel electrochemical sensor for thrombin detection. It utilizes a unique dual signal amplification strategy and potential-assisted gold-sulfur deposition for sensitive and specific quantification.

Keywords:

Thrombin catalytic hairpin assembly electrochemical tetraferrocene

More Related Videos

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Nov 21, 2025

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Area of Science:

Electrochemistry
Biosensors
Biochemistry

Background:

Thrombin detection is crucial for diagnosing and monitoring coagulation disorders.
Existing electrochemical sensors often require complex electrode modification steps.
Development of sensitive and specific thrombin detection methods remains an active area of research.

Purpose of the Study:

To establish a convenient homogeneous electrochemical thrombin sensor.
To implement a dual signal amplification strategy for enhanced sensitivity.
To avoid tedious electrode pre-modification using potential-assisted deposition.

Main Methods:

Potential-assisted gold-sulfur deposition on unmodified gold electrodes.
Synthesis and application of tetraferrocene-modified signal hairpin probes.
Homogeneous assay format with cascade signal amplification.
Quantitative detection using differential pulse voltammetry (DPV).

Main Results:

Achieved a low detection limit for thrombin as 0.06 pmol/L.
Demonstrated high specificity in detecting thrombin against common interfering proteins.
Successfully quantified thrombin using the developed electrochemical sensor.

Conclusions:

The developed sensor offers a convenient and sensitive method for thrombin detection.
The dual signal amplification and potential-assisted deposition strategy are effective.
This approach holds promise for clinical diagnostics and biomedical research.