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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:25

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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Predictors of AVNRT Recurrence After Slow Pathway Modification.

Felix K Wegner1, Pia Habbel1, Piet Schuppert1

  • 1Department of Cardiology II - Electrophysiology, University Hospital Muenster.

International Heart Journal
|January 18, 2021
PubMed
Summary

Recurrence of atrioventricular nodal reentry tachycardia (AVNRT) after slow pathway modification (SPM) is uncommon. Predictors include fewer junctional beats during SPM and a history of atrial fibrillation/tachycardia.

Keywords:
Catheter ablationElectrophysiologySPMSupraventricular tachycardia

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Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Atrioventricular nodal reentry tachycardia (AVNRT) is the most common regular supraventricular tachycardia (SVT).
  • Slow pathway modification (SPM) is the primary treatment, achieving ~95% success.
  • Predictors of AVNRT recurrence post-SPM are not well-established.

Purpose of the Study:

  • To identify predictors of AVNRT recurrence after initially successful SPM.
  • To analyze long-term outcomes in patients requiring repeat SPM.

Main Methods:

  • Retrospective analysis of 4170 patients undergoing SPM from 1993-2018.
  • Identified 78 patients with recurrent AVNRT after >1 SPM.
  • Matched recurrence group with 78 controls who had one successful SPM without recurrence.

Main Results:

  • Recurrence group had fewer junctional beats during SPM (69% vs 89%, P=0.006).
  • Recurrence group had higher rates of prior/inducible atrial fibrillation/tachycardia (AF/AT) (21% vs 5%, P=0.007; 23% vs 6%, P=0.006).
  • Over half of recurrences occurred within the first year, but 20% appeared after 4 years.

Conclusions:

  • AVNRT recurrence post-SPM, though infrequent, is associated with fewer junctional beats during ablation and a higher burden of other arrhythmias.
  • Recurrence can manifest years after initial successful ablation, necessitating continued vigilance.