Related Experiment Video
Updated: Nov 21, 2025
10:55
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
Published on: October 31, 2025
346
Statin-induced necrotizing autoimmune myopathy.
Syed A Huda1, Sanjay Yadava1, Sara Kahlown2
1Department of Internal Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Proceedings (Baylor University. Medical Center)
|January 18, 2021
Summary
Statins can cause a rare autoimmune muscle disease called statin-induced necrotizing autoimmune myopathy (SINAM). Intravenous immunoglobulin effectively treated a patient with this condition.
Area of Science:
- Pharmacology
- Immunology
- Neurology
Background:
- Statins are widely prescribed cholesterol-lowering drugs.
- 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition is their primary mechanism.
- Common side effects include myalgias and elevated liver enzymes.
Observation:
- Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare adverse effect.
- SINAM is independent of statin type and duration.
- It presents as severe muscle weakness and elevated creatine kinase.
Findings:
- Treatment typically involves high-dose steroids and immunosuppressants (azathioprine, methotrexate, mycophenolate mofetil).
- Intravenous immunoglobulin (IVIg) or rituximab are options for non-responders or severe cases.
- This case highlights successful SINAM treatment with IVIg.
Implications:
- Understanding rare statin side effects is crucial for patient safety.
- Immunomodulatory therapies like IVIg offer treatment options for refractory SINAM.
- Further research into the pathogenesis and management of SINAM is warranted.
Related Concept Videos
01:20Myasthenia Gravis: Overview and Treatment
2.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.4K
01:15Myasthenia Gravis: Diagnostic Tests
1.6K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.6K
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.1K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.1K
01:21Myocarditis I: Introduction
162
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
162
01:14Myocarditis III: Medical Management
72
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
72
01:21Satellite Stem Cells and Muscular Dystrophy
2.2K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.2K