A high triglyceride-glucose index is associated with left ventricular dysfunction and atherosclerosis

Area of Science:

• Cardiology
• Metabolic Syndrome
• Vascular Disease

Background:

• The triglyceride-glucose (TyG) index is a recognized, accessible marker for insulin resistance.
• Insulin resistance is a key factor in metabolic and cardiovascular diseases.

Purpose of the Study:

• To examine the relationship between the TyG index and echocardiographic measures of cardiac structure and function.
• To investigate the association of the TyG index with peripheral artery disease indicators.

Main Methods:

• 823 patients (483 males, 340 females) were analyzed retrospectively.
• Multivariable stepwise linear regression was used to identify associations.
• Echocardiographic parameters (LVM, LAD, LVEF) and peripheral artery disease markers (ABI, baPWV) were assessed.

Main Results:

• A higher TyG index was significantly associated with increased left atrial diameter (LAD).
• Elevated TyG index correlated with decreased left ventricular ejection fraction (LVEF).
• Higher TyG index was linked to a lower ankle-brachial index (ABI), indicating peripheral artery disease.

Conclusions:

• The TyG index is significantly associated with left atrial diameter, left ventricular ejection fraction, and ankle-brachial index.
• The TyG index may serve as a valuable indicator for assessing cardiac remodeling, dysfunction, and atherosclerosis in patients with insulin resistance.