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Role of Immune and Autoimmune Dysfunction in Schizophrenia
Emily G Severance1, Robert H Yolken1
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Handbook of Behavioral Neuroscience
|January 18, 2021
Summary
Immune system dysregulation offers a unifying explanation for gene-environment interactions in schizophrenia. Research highlights both innate and adaptive immune system roles in this complex neurodevelopmental disorder.
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Schizophrenia involves complex gene-environment interactions.
- Early research noted humoral immunity and autoimmunity in schizophrenia.
- Current research includes innate immunity in schizophrenia pathogenesis.
Purpose of the Study:
- To review evidence linking immune system dysregulation to schizophrenia.
- To integrate findings on innate and adaptive immunity in schizophrenia.
- To explore the role of inflammation in neurodevelopmental aspects of schizophrenia.
Main Methods:
- Review of existing scientific literature and data.
- Analysis of studies on immune system activation in schizophrenia.
- Integration of findings on neurodevelopment and immunity.
Main Results:
- Immune system dysregulation is a plausible explanation for gene-environment interactions in schizophrenia.
- Aberrant humoral immunity, including autoimmunity, is associated with schizophrenia.
- Innate immune system components are increasingly implicated in schizophrenia.
Conclusions:
- Schizophrenia may result from the interplay between immune and neurodevelopmental dysregulation.
- Understanding inflammation and immune molecules is key to comprehending schizophrenia.
- Immune system dysregulation provides a unifying framework for schizophrenia research.
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