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A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular

Tao Yue1,2, Da Zhao1, Duc T T Phan3

  • 1Department of Biomedical Engineering, University of California, Irvine, CA USA.

Microsystems & Nanoengineering
|January 18, 2021
PubMed
Summary

Researchers developed a novel modular microfluidic system to create large-scale, high-density perfused vascular networks in vitro. This scalable platform supports multiorgan-on-a-chip applications for biological studies and drug screening.

Keywords:
EngineeringMicrofluidics

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Vascular Biology

Background:

  • The human circulatory system's vascular network is crucial for maintaining homeostasis.
  • Generating complex, functional microvascular networks in vitro presents significant challenges.

Purpose of the Study:

  • To develop a novel, scalable modular microfluidic system for creating large-scale perfused microvascular networks in vitro.
  • To enable the creation of high-density, interconnected vascularized tissue models for multiorgan-on-a-chip applications.

Main Methods:

  • A vertical two-layered polydimethylsiloxane (PDMS) microfluidic system was designed and fabricated.
  • Independent design and fabrication of tissue and medium channels with a capillary burst valve interface.
  • Angiogenesis and anastomosis were induced at the vertical interface.

Main Results:

  • Successfully generated large-scale, high-density microvascular networks with quantified vessel length and density.
  • Demonstrated lumenization and tight vertical interconnections via minimal FITC-dextran leakage.
  • Achieved angiogenesis and anastomosis at the vertical interface.

Conclusions:

  • The developed modular microfluidic platform offers high flexibility and scalability for creating complex vascularized tissue models.
  • This system facilitates the culturing of interconnected, large-scale perfused vascular networks.
  • The platform is suitable for advanced applications such as multiorgan-on-a-chip models for drug screening and biological research.