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Bilateral extensive xanthelasma palpebrarum.

A Tosti¹, C Varotti, G Tosti

¹Department of Dermatology, University of Bologna, Italy.

|February 1, 1988

Summary

Xanthelasma palpebrarum can present with severe eyelid disfigurement even without high cholesterol. This case highlights the importance of considering xanthelasma beyond lipid abnormalities.

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Area of Science:

Dermatology
Ophthalmology

Background:

Xanthelasma palpebrarum (XP) is a common xanthoma variant characterized by yellowish deposits on the eyelids.
XP is typically associated with dyslipidemia, particularly elevated low-density lipoprotein (LDL) cholesterol.

Observation:

This report details a rare case of XP with extensive and disfiguring involvement of all four eyelids.
The patient presented with significant cosmetic and functional impairment due to the lesions.

Findings:

Despite the extensive presentation, the patient exhibited normal serum lipid profiles, including total cholesterol, LDL, and triglycerides.
This finding challenges the conventional association between XP and hyperlipidemia.

Implications:

This case underscores that XP can occur in normolipidemic individuals, suggesting other underlying pathogenetic mechanisms.
Further research is warranted to explore non-lipid-related factors contributing to XP development.
Clinicians should consider XP diagnosis irrespective of serum lipid levels, especially in cases of significant eyelid involvement.

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