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A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

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Haplotype analysis for Irish ancestry.

Robert Whiting¹, Heather Miller Coyle¹

¹Forensic Science Department, Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, USA.

Forensic Sciences Research

|January 18, 2021

Summary

This summary is machine-generated.

Forensic Y-chromosome haplotype analysis can identify multiple male contributors in criminal cases and trace ancestral Irish genetic links. This study supports its use in cold case investigations and ancestral footprint research.

Keywords:

DNA DNA dragnet Forensic sciences Y chromosome familial search forensic genetics haplotype analysis

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Area of Science:

Forensic genetics
Population genetics
Human genetics

Background:

Y-chromosome haplotype analysis is crucial in forensic science for identifying male DNA in complex samples and determining the number of male contributors.
Its application extends to biogeographic studies for ancestry correlation with founder populations.

Purpose of the Study:

To evaluate the utility of Y-chromosome analysis in a "dragnet" approach for cold case investigations, similar to its use in solving sex assault and homicide cases.
To investigate the potential for identifying an ancestral Irish genetic "footprint" and its correlation with the O'Brien surname and Dal Riata haplotype.

Main Methods:

Forensic haplotype analysis of the male Y chromosome.
DNA profiling from trace amounts of male DNA in the presence of excess female DNA.
Biogeographic and population genetic analyses to identify founder groups and ancestral haplotypes.

Main Results:

The study supports the potential of Y-chromosome analysis as a "dragnet" tool for identifying unique haplotypes in forensic investigations.
Multiple founder group origins in Ireland and England were identified.
Three samples exhibited the Dal Riata ancestral haplotype, indicating a correlation with ancestral Irish ancestry, but not conclusively with the O'Brien surname.

Conclusions:

Y-chromosome haplotype analysis is a valuable tool for forensic investigations, particularly in identifying multiple male donors and in cold case scenarios.
The study demonstrates a correlation between Y-chromosome haplotypes and ancestral Irish populations, including the Dal Riata, but further research is needed to confirm surname-specific links.