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Ferroptosis becomes immunogenic: implications for anticancer treatments

Daolin Tang1, Oliver Kepp2,3, Guido Kroemer2,3,4,5,6

  • 1Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

Oncoimmunology
|January 18, 2021
PubMed
Summary

Ferroptosis, an iron-dependent cell death, triggers an immune response by releasing damage-associated molecular patterns (DAMPs). This process matures dendritic cells and can protect against fibrosarcoma in preclinical models.

Keywords:
Damage-associated molecular patternanticancer vaccinationdendritic cells

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