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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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Related Experiment Video

Updated: Nov 21, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Meningoencephalitis Associated with SARS-Coronavirus-2.

G Iaconetta1, P De Luca1, A Scarpa1

  • 1Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

Translational Medicine @ Unisa
|January 18, 2021
PubMed
Summary
This summary is machine-generated.

Meningitis and encephalitis are common neurological complications in patients with COVID-19. This review highlights the incidence and potential mechanisms behind these serious conditions.

Keywords:
COVID-19EncephalitisMeningitisSars-Coronavirus-2neurological complications

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • Neurological manifestations are increasingly recognized in patients with COVID-19.
  • Meningitis and encephalitis represent significant, though not fully understood, complications of SARS-CoV-2 infection.

Purpose of the Study:

  • To clarify the incidence of meningitis and encephalitis in patients with SARS-CoV-2 (COVID-19).
  • To review existing literature on neurological complications, specifically meningoencephalitis, in COVID-19 patients.

Main Methods:

  • A comprehensive literature search was performed using PubMed with MeSH terms: "meningitis," "encephalitis," and "COVID-19."
  • Included studies were case series, case reports, and review articles detailing neurological symptoms in COVID-19 patients.
  • Twenty studies reporting encephalitis and/or meningitis were included in this narrative review after screening and eligibility assessment.

Main Results:

  • Neurological manifestations, particularly meningoencephalitis, are not rare in COVID-19 patients.
  • Hypoxic/metabolic changes resulting from the inflammatory cytokine storm can lead to encephalopathy.
  • Comorbidities and pre-existing neurological conditions, like Alzheimer's disease, may increase susceptibility.

Conclusions:

  • Meningoencephalitis is a notable neurological complication associated with SARS-CoV-2 infection.
  • Further research is essential to elucidate the underlying biological mechanisms of these neurological complications.