Epstein-Barr Virus-induced Meningitis-Retention Syndrome

Morika Suzuki1, Genya Watanabe2, Takashi Watari3

  • 1Department of General Internal Medicine, National Hospital Organization Sendai Medical Center, Miyagi, Japan.

Insights

Meningitis-retention syndrome (MRS), a rare condition causing aseptic meningitis and urinary retention, can be mistaken for a urinary tract infection. Early consideration of MRS is crucial in patients with fever and urinary issues, as bladder symptoms may appear before meningitis signs.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Urology

Background:

  • Meningitis-retention syndrome (MRS) is a rare condition characterized by aseptic meningitis and urinary retention.
  • MRS is often misdiagnosed as a urinary tract infection due to overlapping symptoms like dysuria.
  • Prompt diagnosis and management are essential to prevent complications.

Purpose of the Study:

  • To highlight the clinical presentation of Meningitis-retention syndrome (MRS).
  • To emphasize the importance of considering MRS in patients presenting with fever and urinary retention.
  • To report a case of MRS associated with Epstein-Barr virus.

Main Methods:

  • Case report of a 55-year-old male patient.
  • Clinical evaluation including assessment of fever, dysuria, and signs of meningeal irritation.
  • Diagnostic investigations to identify the underlying cause, including Epstein-Barr virus testing.

Main Results:

  • The patient presented with fever and dysuria, initially mimicking a urinary tract infection.
  • Meningeal irritation signs developed later in the disease course.
  • Epstein-Barr virus was identified as the causative agent for MRS in this case.

Conclusions:

  • Meningitis-retention syndrome (MRS) requires consideration in patients with unexplained fever and urinary retention.
  • Dysuria can be an early symptom preceding overt meningitis in MRS.
  • Epstein-Barr virus is a potential complicating factor in MRS.

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...