Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unexplained lymphadenopathy in sickle cell disease.

A J Keidan1, M D Hamon, I M Franklin

  • 1Department of Haematology, Medical School, University of Birmingham, U.K.

European Journal of Haematology
|February 1, 1988
PubMed
Summary

A previously healthy woman with sickle cell disease (SCD) developed progressive lymphadenopathy due to human immunodeficiency virus (HIV) infection. Risk factors included travel-related parenteral therapy and heterosexual contact, highlighting potential HIV risks in SCD patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood transfusion safety: a new philosophy.

Transfusion medicine (Oxford, England)·2012
Same author

Routine antenatal anti-D prophylaxis.

Transfusion medicine (Oxford, England)·2012
Same author

Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy.

Bone marrow transplantation·2011
Same author

Pathogen inactivation of platelet concentrates.

Vox sanguinis·2010
Same author

Selection of CD34+ cells from cryopreserved PBPC can be significantly improved by the addition of recombinant human DNase (Pulmozyme).

Cytotherapy·2009
Same author

Section 1: medical informatics and eHealth.

Technology and health care : official journal of the European Society for Engineering and Medicine·2009

Area of Science:

  • Infectious Diseases
  • Hematology
  • Immunology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder affecting red blood cells.
  • Patients with SCD may have altered immune function, but their susceptibility to certain infections is not fully understood.
  • Progressive lymphadenopathy can indicate various underlying conditions, including infections.

Observation:

  • A previously healthy adult female with homozygous SCD presented with progressive lymphadenopathy.
  • Initial presentation mimicked other conditions, delaying the diagnosis of HIV infection.
  • Thorough patient history revealed potential risk factors for HIV exposure.

Findings:

  • The lymphadenopathy was definitively diagnosed as being caused by HIV infection.

Related Experiment Videos

  • Identified risk factors included parenteral therapy and heterosexual contact during international travel.
  • This case underscores that SCD patients, even those appearing low-risk, can be susceptible to HIV.

    • Implications:

    • SCD patients require careful consideration of infectious disease risks, including HIV, especially when traveling or undergoing medical procedures abroad.
    • Healthcare providers should maintain a high index of suspicion for opportunistic infections like HIV in SCD patients presenting with unexplained symptoms.
    • Further research is needed to clarify the interplay between SCD-related immunological abnormalities and susceptibility to HIV infection.