Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prognostic parameters in myelodysplastic syndromes: a multiple regression analysis.

A Riccardi1, M Giordano, P Giordano

  • 1Istituto di Clinica Medica II, Dipartimento di Medicina Interna e Terapia Medica, Matteo, Pavia, Italy.

European Journal of Haematology
|February 1, 1988
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normal, dust-obscured galaxies in the epoch of reionization.

Nature·2021
Same author

Association of quantitative MRI-based radiomic features with prognostic factors and recurrence rate in oropharyngeal squamous cell carcinoma.

Neoplasma·2020
Same author

The association between duration of remission, fatigue, depression and health-related quality of life in Italian patients with systemic lupus erythematosus.

Lupus·2019
Same author

Evaluation of the influence of social, demographic, environmental, work-related factors and/or lifestyle habits on Raynaud's phenomenon: a case-control study.

Clinical and experimental medicine·2019
Same author

Validation of a short questionnaire to record adherence to the Mediterranean diet: An Italian experience.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018
Same author

Primary prevention of cardiovascular disease in patients with systemic lupus erythematosus: case series and literature review.

Lupus·2017

Five key factors, including hemoglobin and bone marrow cellularity, significantly predict survival in myelodysplastic syndromes (MDS) patients. High bone marrow cellularity is the strongest indicator for leukemia development in MDS.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Medicine

Background:

  • Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
  • Accurate prognostic factors are crucial for managing MDS patients and predicting outcomes.
  • Identifying key clinical and hematologic parameters influencing survival is essential for treatment stratification.

Purpose of the Study:

  • To evaluate the influence of 21 basic clinical and hematologic parameters on survival in previously untreated myelodysplastic syndromes (MDS) patients.
  • To identify significant predictors of survival and acute leukemia development in MDS.
  • To develop a predictive model for MDS patient survival using identified prognostic factors.

Main Methods:

  • Survival analysis using Kaplan-Meier curves.

Related Experiment Videos

  • Multiple regression analysis to assess the significance of 21 clinical and hematologic parameters.
  • Evaluation of 72 patients with previously untreated myelodysplastic syndromes.

    • Main Results:

    • Five parameters significantly influenced survival: hemoglobin level, bone marrow cellularity, bone marrow blast percentage, age, and bone marrow erythro/myeloid (E/M) ratio.
    • Multiple regression analysis predicted 34% of survival in all MDS patients (p < 0.002).
    • High bone marrow cellularity was the most predictive factor for leukemia development; no factor predicted death from cytopenic complications.

    Conclusions:

    • Hemoglobin, bone marrow cellularity, blast percentage, age, and E/M ratio are key prognostic factors in MDS.
    • A predictive model incorporating these factors can estimate survival in MDS patients.
    • Bone marrow cellularity is a critical indicator for predicting acute leukemia transformation in MDS.