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Updated: Nov 21, 2025
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments
Shaoxin Deng1,2, Cheng-Xing Cui1,3, Lingyao Duan1
1Postdoctoral Research Base, School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China.
Abstract:
Targeted release of anticancer drugs to tumor sites has a pivotal role in clinical oncology. pH-responsive drug delivery systems, with an intelligent and targeted release of anticancer drugs in a controllable manner based on sensitivities to the weakly acidic environments of tumor cellular microenvironments, are desirable. Herein, the design of such a pH-responsive drug delivery system is detailed using in situ amino-functionalized hollow mesoporous silica nanoparticles as carriers. The drug release behavior of the pH-responsive delivery system was evaluated under an in vitro simulation of tumor cellular microenvironments. The drug delivery system has efficient drug loadings and targeted release. Zorubicin hydrochloride releasing percentage is almost up to 100% at a buffer pH of 5.0. The drug release systems described demonstrating great potential in anticancer therapy.
Insights
This study details a pH-responsive drug delivery system using amino-functionalized silica nanoparticles for targeted anticancer drug release. The system shows efficient drug loading and release, demonstrating potential for cancer therapy.
Area of Science:
- Nanotechnology
- Oncology
- Materials Science
Background:
- Targeted drug delivery to tumors is crucial in oncology.
- pH-responsive systems offer controlled release in tumor microenvironments.
- Current systems require intelligent design for enhanced efficacy.
Purpose of the Study:
- To design and detail a pH-responsive drug delivery system.
- To utilize amino-functionalized hollow mesoporous silica nanoparticles as carriers.
- To evaluate the drug release behavior in simulated tumor microenvironments.
Main Methods:
- In situ amino-functionalization of hollow mesoporous silica nanoparticles.
- Loading of anticancer drugs (Zorubicin hydrochloride).
- In vitro evaluation of drug release at pH 5.0.
Main Results:
- The developed system demonstrated efficient drug loading.
- Targeted and controllable drug release was observed.
- Zorubicin hydrochloride release reached nearly 100% at pH 5.0.
Conclusions:
- The pH-responsive drug delivery system shows significant potential for anticancer therapy.
- Amino-functionalized silica nanoparticles are effective carriers for targeted drug release.
- The system's sensitivity to acidic tumor microenvironments enables controlled drug delivery.
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