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Neuropathic Pain: Unexplored and Significant Relationship With Psoriatic Arthritis and Functional Parameters
Çağrı Ünal Ulutatar1, Fırat Ulutatar2, Mehmet Tuncay DuruÖz3
1Department of Physical Medicine and Rehabilitation, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Turkey.
Archives of Rheumatology
|January 18, 2021
Summary
Neuropathic pain (NP) is common in psoriatic arthritis (PsA) and significantly impacts quality of life, sleep, and fatigue. Early NP assessment in PsA patients is crucial for effective treatment strategies.
Area of Science:
- Rheumatology
- Neurology
- Pain Medicine
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition.
- Neuropathic pain (NP) is a complex pain condition.
- The prevalence and impact of NP in PsA are not fully understood.
Purpose of the Study:
- To investigate the presence of neuropathic pain (NP) in patients with psoriatic arthritis (PsA).
- To explore the relationship between NP and functional parameters such as quality of life, sleep, and fatigue in PsA patients.
Main Methods:
- Fifty PsA patients were assessed for NP using the PainDETECT questionnaire (PDQ).
- Quality of life (QoL), sleep quality, and fatigue were evaluated using the Psoriatic Arthritis Quality of Life (PsAQoL), Pittsburgh Sleep Quality Index (PSQI), and Multidimensional Assessment of Fatigue (MAF) scales.
- Statistical analyses included Mann-Whitney U, Kruskal-Wallis, and Spearman's rank correlation tests.
Main Results:
- Neuropathic pain was detected in a significant proportion of PsA patients (likely NP in 12, ambiguous in 8).
- Patients with NP reported significantly higher scores for pain, sleep disturbances (PSQI), impaired QoL (PsAQoL), and fatigue (MAF).
- Moderate to strong correlations were observed between NP (PDQ scores) and functional parameters: PSQI (rho=0.44), MAF (rho=0.42), and PsAQoL (rho=0.73).
Conclusions:
- Neuropathic pain is not uncommon in psoriatic arthritis.
- NP in PsA is significantly associated with reduced quality of life and sleep disturbances.
- Routine assessment of NP in PsA patients is recommended for comprehensive management.
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