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Sixteen Weeks Later: Expanding the Risk Period for Multisystem Inflammatory Syndrome in Children

Blake T Cirks1,2,3, Samantha J Rowe1, Sarah Y Jiang1

  • 1Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Journal of the Pediatric Infectious Diseases Society
|January 18, 2021
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) typically follows COVID-19 within weeks. This case reveals MIS-C can occur up to 16 weeks after infection, extending the risk window.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Public health

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition linked to COVID-19.
  • The typical onset of MIS-C occurs 2-6 weeks after SARS-CoV-2 infection or exposure.

Observation:

  • This report details a unique case of MIS-C.
  • The patient presented with MIS-C symptoms 16 weeks post-initial COVID-19 illness.

Findings:

  • The case demonstrates a significantly prolonged interval between COVID-19 and MIS-C onset.
  • This challenges the previously understood typical 2-6 week timeframe for MIS-C development.

Implications:

  • The findings suggest an extended window of vulnerability for MIS-C development in children post-COVID-19.
  • Healthcare providers should consider MIS-C in children presenting with relevant symptoms even several months after infection.
  • This highlights the need for ongoing surveillance and research into the long-term effects of COVID-19 in pediatric populations.

Keywords:
multisystem inflammatory syndrome in childrenmyocarditisnovel coronavirus 2019severe acute respiratory syndrome coronavirus 2

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