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Related Experiment Video

Updated: Nov 21, 2025

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
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A Programmable DNA-Silicification-Based Nanocavity for Single-Molecule Plasmonic Sensing.

Le Liang1, Peng Zheng1, Chi Zhang1

  • 1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Advanced Materials (Deerfield Beach, Fla.)
|January 18, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed DNA-silicified template for Raman optical beacon (DNA-STROBE) nanocavities for advanced optical sensing. These robust structures enable single-molecule detection and visualization of plasmonic hotspots using surface-enhanced Raman spectroscopy (SERS).

Keywords:
DNA silicificationhotspotsplasmonic nanocavitiessingle-molecule surface enhance Raman scatteringsuper-resolution imaging

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Area of Science:

  • Nanophotonics
  • Biomedical Sciences
  • Materials Science

Background:

  • Plasmonic nanocavities offer unparalleled light confinement for optical sensing.
  • Fabricating stable, high-fidelity nanocavities and visualizing plasmonic hotspots remain significant challenges.

Purpose of the Study:

  • To engineer robust, high-fidelity plasmonic nanocavities for enhanced optical sensing.
  • To enable noninvasive visualization of plasmonic hotspots and single-molecule detection.

Main Methods:

  • Utilizing silicified DNA scaffolds to organize discrete plasmonic nanoparticles into DNA-silicified template for Raman optical beacon (DNA-STROBE) constructs.
  • Employing super-resolution surface-enhanced Raman spectroscopy (SERS) for hotspot profiling and molecular detection.

Main Results:

  • DNA-STROBE nanocavities demonstrate enhanced structural stability, chemical inertness, and precise nanogap control.
  • Achieved large, controlled local electromagnetic field enhancement and single-molecule SERS detection at elevated concentrations.
  • Enabled diffraction-unlimited spatial profiling of plasmonic hotspots.

Conclusions:

  • DNA-STROBE provides a versatile, reproducible platform for label-free molecular detection.
  • The technology significantly advances nanophotonics and opens new avenues in biomedical sensing.