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Bioactive isocoumarins isolated from a mangrove-derived fungus Penicillium sp. MGP11
Rong-Qing Mei1,2, Bin Wang1,2, Wei-Nv Zeng1,2
1Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
Abstract:
Two new isocoumarins penicimarins L-M (1-2), along with seven known analogues (3-9) were isolated from the mangrove-derived fungus Penicillium sp. MGP11. Compounds 1-2 were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature. All isolated compounds were evaluated for antioxidant and α-glucosidase inhibitory activities. Compound 8 had better antioxidant activity (IC50 = 4.6 μM) than positive control trolox (IC50 = 12.9 μM). Compounds 5, 8 and 9 exhibited α-glucosidase inhibitory activity with the IC50 values of 776.5, 683.7 and 868.7 μM, respectively.[Formula: see text].
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