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Updated: Nov 21, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Estimation of COVID-19 epidemic curves using genetic programming algorithm.

Nikola Anđelić1, Sandi Baressi Šegota1, Ivan Lorencin1

  • 1University of Rijeka, Faculty of Engineering, Rijeka, Croatia.

Health Informatics Journal
|January 18, 2021
PubMed
Summary
This summary is machine-generated.

Genetic Programming (GP) models accurately estimate COVID-19 confirmed, deceased, and recovered cases. The developed mathematical models closely predict country-specific and global epidemiology curves using real-world data.

Keywords:
COVID-19disease spread modelingevolutionary computinggenetic programmingmachine learning

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Area of Science:

  • Computational Biology
  • Epidemiology
  • Machine Learning

Background:

  • The COVID-19 pandemic necessitated accurate forecasting of disease spread.
  • Mathematical modeling is crucial for understanding and predicting epidemiological trends.
  • Genetic Programming (GP) offers a powerful approach for deriving complex mathematical models from data.

Purpose of the Study:

  • To implement the Genetic Programming (GP) algorithm for modeling COVID-19 cases.
  • To develop predictive mathematical models for confirmed, deceased, and recovered cases.
  • To estimate and validate the epidemiology curve for selected countries and globally.

Main Methods:

  • Application of the Genetic Programming (GP) algorithm.
  • Utilizing a publicly available COVID-19 dataset.
  • Developing and evaluating mathematical models based on R-squared scores.

Main Results:

  • High accuracy achieved: R-squared scores of 0.999 for confirmed and deceased cases.
  • Excellent performance for recovered cases with an R-squared score of 0.998.
  • Generated models accurately estimated epidemiology curves, closely matching real-world data.

Conclusions:

  • Genetic Programming (GP) is a viable method for creating accurate COVID-19 predictive models.
  • The derived mathematical models effectively forecast epidemiological trends.
  • The study validates the utility of GP in public health data analysis and prediction.