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Updated: Nov 21, 2025

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages
Published on: November 1, 2019
Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis
Thomas M Hofbauer1, Anna S Ondracek1, Irene M Lang2
1Department of Cardiology, Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Abstract:
Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (NET) formation, linking innate immunity with acute complications of atherosclerosis. In this chapter, we summarize mechanisms of NET formation, evidence for their involvement in atherosclerosis and thrombosis, and potential therapeutic regimens specifically targeting NET components.
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