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Metal artifact reduction for improving quantitative SPECT/CT imaging.

Takahiro Konishi1, Takayuki Shibutani2, Koichi Okuda3

  • 1Department of Radiology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Annals of Nuclear Medicine
|January 18, 2021
PubMed
Summary

Metal artifact reduction (MAR) significantly improves quantitative accuracy in SPECT/CT imaging for patients with metal implants. This iterative MAR (iMAR) method enhances diagnostic reliability by reducing quantification errors, regardless of CT dose.

Keywords:
Artificial jointIterative metal artifact reductionQuantitative SPECT/CTRadioactivity concentration

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Area of Science:

  • Medical Imaging
  • Radiology
  • Nuclear Medicine

Background:

  • Metal implants in patients undergoing SPECT/CT imaging cause artifacts that compromise quantitative accuracy.
  • Metal artifacts lead to under- or overestimation of radioactivity concentration in SPECT/CT scans.
  • Accurate quantification is crucial for effective diagnosis and treatment monitoring in nuclear medicine.

Purpose of the Study:

  • To evaluate the impact of iterative metal artifact reduction (iMAR) on quantitative SPECT/CT accuracy.
  • To determine the usefulness of iMAR in SPECT/CT imaging of patients with metal implants.
  • To assess if iMAR improves quantitative accuracy independent of CT radiation dose.

Main Methods:

  • A phantom study simulating hip prostheses was conducted using SPECT/CT with iMAR.
  • Quantitative SPECT images were reconstructed using CT data with and without iMAR at varying CTDIvols (1.4, 2.8, 5.6 mGy).
  • Radioactivity concentrations were measured in artifact and non-artifact regions of interest (ROIs) to assess quantitative accuracy.

Main Results:

  • Without iMAR, quantification errors ranged from -41.1% to +20.0% in artifact areas.
  • iMAR reduced quantification errors to a range of -22.8% to +14.2%.
  • The mean absolute error in artifact regions decreased from 4.00 to 1.74 kBq/mL with iMAR, with no significant difference in non-artifact areas.

Conclusions:

  • Iterative metal artifact reduction (iMAR) effectively improves quantitative accuracy in SPECT/CT.
  • iMAR is a valuable tool for enhancing SPECT/CT imaging in patients with metal implants.
  • The benefits of iMAR are consistent across different CT radiation doses.