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Related Experiment Videos

Butacote: the first assessment in general practice.

W A Rushford, P D Fowler

    The Journal of International Medical Research
    |January 1, 1977
    PubMed
    Summary
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    Enteric-coated phenylbutazone (Butacote) offers superior gastrointestinal tolerance compared to standard phenylbutazone (Butazolidine) for rheumatic conditions. Patient preference strongly favored Butacote due to reduced dyspeptic symptoms.

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Rheumatic conditions require effective and well-tolerated treatments.
    • Phenylbutazone is a treatment option, but gastrointestinal side effects can occur.
    • Evaluating different formulations of phenylbutazone is crucial for patient care.

    Purpose of the Study:

    • To compare the efficacy and tolerance of standard phenylbutazone (Butazolidine) versus enteric-coated phenylbutazone (Butacote).
    • To assess patient preference between the two phenylbutazone formulations in a general practice setting.

    Main Methods:

    • A double-blind, crossover trial involving fifty patients with rheumatic conditions.
    • Patients received 100 mg of standard phenylbutazone (Butazolidine) and enteric-coated phenylbutazone (Butacote) for one week each.

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  • Effectiveness, tolerance (dyspeptic symptoms), and patient preference were recorded.

    • Main Results:

    • No significant difference in therapeutic effectiveness was observed between Butazolidine and Butacote.
    • Nine patients reported dyspeptic symptoms with standard phenylbutazone, while none reported symptoms with Butacote.
    • A significant patient preference (17:7) favored Butacote, primarily due to improved gastrointestinal tolerance.

    Conclusions:

    • Enteric-coated phenylbutazone (Butacote) demonstrates superior gastrointestinal tolerance compared to standard phenylbutazone (Butazolidine).
    • Butacote is a preferred formulation for managing rheumatic conditions when phenylbutazone is indicated, due to reduced dyspeptic symptoms.
    • The enhanced tolerance of Butacote significantly improves patient compliance and overall treatment experience.