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Sofosbuvir plus ribavirin combination regimen boost liver functions and antioxidant profile in hepatitis C virus

Omayma A Ragab AboZaid1, Mohamed K Mahfouz1, Omneia M Abdel Hammed1

  • 1Department of Biochemistry, Benha University, Egypt.

Microbial Pathogenesis
|January 18, 2021
PubMed

Insights

Treatment with Sofosbuvir and Ribavirin significantly improved liver function and antioxidant profiles in Hepatitis C virus patients. This combination therapy offers a promising approach for managing liver damage caused by the Hepatitis C virus.

Area of Science:

  • Hepatology
  • Virology
  • Biochemistry

Background:

  • Hepatitis C virus (HCV) infection is a major global health concern, causing significant liver damage and contributing to morbidity and mortality.
  • Effective antiviral therapies are crucial for managing HCV and preventing its long-term consequences.

Purpose of the Study:

  • To evaluate the impact of combined Sofosbuvir and Ribavirin therapy on liver function and antioxidant status in patients with Hepatitis C virus infection.

Main Methods:

  • A study involving 30 Hepatitis C virus patients and 10 healthy volunteers was conducted.
  • Liver function tests and antioxidant profiles were assessed before and after treatment with Sofosbuvir and Ribavirin.

Main Results:

  • Treatment led to a significant decrease in elevated liver enzymes (ALT, AST, ALP), bilirubin, and AFP.
  • Significant improvements were observed in antioxidant enzyme activities, including glutathione peroxidase, catalase, and superoxide dismutase.
  • Levels of L-Malondialdhyde, albumin, and total protein also showed significant changes indicating improved liver health.

Conclusions:

  • Combination therapy with Sofosbuvir and Ribavirin effectively improves liver function parameters in Hepatitis C virus patients.
  • This treatment regimen also enhances the body's antioxidant defense system, mitigating oxidative stress associated with HCV infection.

Keywords:
Antioxidant systemAntiviral drugsHepatic enzymesViral hepatitis

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