Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

2.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
2.8K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.2K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient and Physician Global Disease Assessments in Systemic Sclerosis: Distinct and Complementary Constructs.

Arthritis care & research·2026
Same author

Does the ACR/EULAR Total Improvement Score Reflect How Individuals With Autoimmune Inflammatory Myopathies Feel and Function?

The Journal of rheumatology·2026
Same author

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis care & research·2026
Same author

Mouse models of immune-related adverse events: progress, challenges, and opportunities.

Trends in cancer·2026
Same author

Umbilical cord mesenchymal stromal cells for respiratory complications of COVID-19 infection (ProTrans): phase II randomized clinical trial.

Cytotherapy·2026
Same author

Comment on: Prevalence, distribution and associations of the scleroderma capillaroscopic patterns: new insights from the Italian SPRING-SIR registry.

Rheumatology (Oxford, England)·2026

Related Experiment Video

Updated: Nov 21, 2025

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.2K

Trigeminal neuralgia in systemic sclerosis.

Nancy Maltez1, May Y Choi2, Yves Troyanov3

  • 1Department of Medicine, Division of Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada.

Seminars in Arthritis and Rheumatism
|January 18, 2021
PubMed
Summary

Trigeminal neuralgia (TN) is clinically associated with systemic sclerosis (SSc), particularly with inflammatory myositis and arthritis. This suggests inflammation and fibrosis may contribute to TN in SSc patients.

Keywords:
Anti-nuclear envelope (NE) antibodiesSystemic sclerosisTrigeminal neuralgia

More Related Videos

Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies
05:38

Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies

Published on: March 8, 2024

2.4K
Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury
04:39

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury

Published on: February 9, 2024

2.8K

Related Experiment Videos

Last Updated: Nov 21, 2025

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.2K
Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies
05:38

Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies

Published on: March 8, 2024

2.4K
Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury
04:39

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury

Published on: February 9, 2024

2.8K

Area of Science:

  • Rheumatology
  • Neurology
  • Systemic Autoimmune Diseases

Background:

  • Trigeminal neuralgia (TN) is occasionally observed in patients with systemic sclerosis (SSc).
  • The underlying pathophysiological mechanisms linking TN and SSc remain largely unknown.
  • Limited evidence exists on the clinical association between these two conditions.

Purpose of the Study:

  • To investigate the association between TN and SSc in a large, multi-centered cohort.
  • To identify potential pathophysiological links between TN and SSc.
  • To determine the prevalence and incidence of TN among SSc patients.

Main Methods:

  • A nested case-control study was conducted using data from 1652 SSc subjects.
  • Cases with physician-reported TN (prevalent and incident) were identified and matched to controls without TN.
  • Sociodemographic, clinical, and serological characteristics were compared between cases and controls.

Main Results:

  • At baseline, 2.6% of SSc subjects had TN; incidence during follow-up was 5.8 per 1000 person-years.
  • Prevalent TN cases showed significantly higher rates of inflammatory myositis and inflammatory arthritis compared to controls.
  • Incident TN cases also exhibited increased prevalence of inflammatory myositis and inflammatory arthritis.

Conclusions:

  • This study provides novel evidence linking TN with inflammatory myositis and inflammatory arthritis in SSc patients.
  • The findings suggest that inflammatory and fibrotic processes, in addition to ischemia, may underlie TN in the context of SSc.
  • Further research into these pathophysiological links is warranted.