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CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer

Pin-Shern Chen1, Hui-Ping Hsu2, Nam Nhut Phan3

  • 1Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 70101, Taiwan, Republic of China.

Aging
|January 18, 2021
PubMed

Insights

Coiled-coil domain-containing protein 167 (CCDC167) is upregulated in breast cancer, promoting tumor growth. Targeting CCDC167 may offer a new therapeutic strategy for breast cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cause of new cancer cases in American women, with estrogen receptor (ER)-positive cancers playing a significant role.
  • Estrogen's crucial role in ER-positive breast cancer necessitates identifying novel therapeutic targets and understanding downstream pathways.
  • The specific role of coiled-coil domain-containing protein 167 (CCDC167) in breast cancer development and progression remained largely uncharacterized.

Purpose of the Study:

  • To investigate the role of CCDC167 in breast cancer.
  • To determine if CCDC167 expression correlates with patient prognosis.
  • To evaluate CCDC167 as a potential therapeutic target for breast cancer.

Main Methods:

  • Bioinformatics screening using multiple databases (ONCOMINE, MetaCore, IPA, Kaplan-Meier Plotter).
  • Analysis of CCDC167 expression levels in relation to breast cancer patient prognoses.
  • Experimental validation including CCDC167 knockdown and assessment of its effect on cancer cell growth and proliferation.
  • Investigation of CCDC167 expression changes in response to standard chemotherapy agents (fluorouracil, carboplatin, paclitaxel, doxorubicin) in MCF-7 cells.

Main Results:

  • CCDC167 was found to be upregulated across various tumor types.
  • High CCDC167 expression levels were significantly associated with poor prognoses in breast cancer patients.
  • Knockdown of CCDC167 suppressed aggressive breast cancer growth and proliferation.
  • Chemotherapy treatments led to decreased CCDC167 expression and suppressed MCF-7 cell growth.

Conclusions:

  • CCDC167 plays a significant role in promoting breast cancer growth and progression.
  • CCDC167 expression is a potential biomarker for predicting poor patient outcomes.
  • CCDC167 represents a promising novel therapeutic target for breast cancer treatment.
Keywords:
bioinformaticsbreast cancercell growthcell proliferationcoiled-coil domain-containing protein 167

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