A novel ratiometric electrochemical cupric ion sensing strategy based on unmodified electrode

In this paper, a novel ratiometric electrochemical Cu(II) sensing strategy was established by monitoring the changes of the reduction peaks of Cu(II) and paracetamol based on bare electrode. The paracetamol was adopted as an optimal ratiometric reference (rather than classic ferrocene (Fc) and methylene blue (MB)) due to its highly stability and suitable reduction peak, which is well-separated from the reduction peak of Cu(II). Adopting paracetamol as the internal reference, the reproducibility of this sensing strategy was obviously enhanced. The sensing platform is very cheap in cost and avoids some time-consuming electrode modification process, which is helpful for low-cost and rapid detection.