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Updated: Jul 15, 2026

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Current Challenges for Fasciolicide Treatment in Ruminant Livestock.

José Antonio Castro-Hermida1, Marta González-Warleta1, Victoria Martínez-Sernández2

  • 1Laboratory of Parasitology, Centro de Investigaciones Agrarias de Mabegondo, AGACAL, Abegondo, A Coruña, Spain.

Trends in Parasitology
|January 19, 2021
PubMed
Summary

Controlling fasciolosis in livestock is crucial, but challenges like limited flukicide options and unclear drug withdrawal information hinder treatment. Harmonizing flukicide use and monitoring efficacy are vital for animal health and trade.

Keywords:
Fasciolaanthelminticflukicideruminanttriclabendazoleveterinary drug

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Area of Science:

  • Veterinary Parasitology
  • Drug Efficacy and Safety

Background:

  • Fasciolosis is a significant parasitic disease in ruminant livestock, necessitating effective pharmacological control in endemic regions.
  • Current flukicide treatments face challenges, including limited availability for early-stage infections and inadequate or contradictory information on drug withdrawal periods in package leaflets.

Purpose of the Study:

  • To review the current landscape of flukicide formulations available for livestock treatment.
  • To analyze the constraints associated with treating fasciolosis in food-producing animals, particularly in the European Union and other global regions.
  • To highlight the need for regulatory harmonization and efficacy monitoring of flukicides.

Main Methods:

  • This paper is a review of existing literature and regulatory information on flukicide use in livestock.
  • Analysis of flukicide availability, formulation, and associated information provided in package inserts.
  • Comparative overview of flukicide situations in the European Union versus non-European countries.

Main Results:

  • Significant limitations exist in flukicide availability for early Fasciola infections in ruminants in certain countries.
  • Package leaflet information regarding withdrawal periods is frequently incomplete, confusing, or contradictory, impacting food safety and trade.
  • There is a critical need for standardized international guidelines for flukicide use.

Conclusions:

  • Harmonization of flukicide regulations by international bodies is essential for equitable and safe international trade.
  • Continuous monitoring of fasciolicide efficacy on farms is crucial to prevent the emergence and spread of drug-resistant Fasciola populations.
  • Addressing current limitations in flukicide treatment is vital for effective fasciolosis control in livestock globally.