Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

201
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
201
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.4K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.8K
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

133
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
133
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.3K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

124
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
124

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood Underweight and Adulthood Obesity Associated With Increased Risk of MASLD and Cirrhosis: A Prospective Cohort Study of 375,125 Adults.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same author

Nanotechnology in reproductive medicine: from gamete engineering to precision therapeutics.

RSC advances·2026
Same author

Chrysin alleviates pressure overload-induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway-mediated oxidative stress response.

Animal models and experimental medicine·2026
Same author

Enhanced Electrochemiluminescence by Nanocatalyst-Supported Nanochannel-Surfactant Micelle Assembly for Ultrasensitive Detection of Rifampicin.

Biosensors·2026
Same author

Comparative efficacy and safety of different acupuncture therapies for insomnia in breast cancer patients: A systematic review and Bayesian network meta-analysis.

Complementary therapies in clinical practice·2026
Same author

A pilot study on the feasibility of using GPT-5.0 for objective esthetic assessment of single-tooth restorations.

Journal of prosthodontic research·2026

Related Experiment Video

Updated: Nov 21, 2025

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.0K

Neurovascular coupling alterations in type 2 diabetes: a 5-year longitudinal MRI study.

Yang Zhang1, Xiaolu Zhang1, Guangyang Ma2

  • 1Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

BMJ Open Diabetes Research & Care
|January 19, 2021
PubMed
Summary

Type 2 diabetes mellitus (T2DM) accelerates neurovascular coupling impairment, particularly in the left insula, leading to memory decline. The mReHo:mCBF ratio may serve as an imaging marker for these changes.

Keywords:
central nervous systemcognitive neurosciencediabetes mellitusmagnetic resonance imagingtype 2

More Related Videos

Author Spotlight: Unlocking New Insights in fNIRS Studies - A Novel Framework for Inter-Brain Synchrony Analysis
05:59

Author Spotlight: Unlocking New Insights in fNIRS Studies - A Novel Framework for Inter-Brain Synchrony Analysis

Published on: October 6, 2023

3.0K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.0K

Related Experiment Videos

Last Updated: Nov 21, 2025

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.0K
Author Spotlight: Unlocking New Insights in fNIRS Studies - A Novel Framework for Inter-Brain Synchrony Analysis
05:59

Author Spotlight: Unlocking New Insights in fNIRS Studies - A Novel Framework for Inter-Brain Synchrony Analysis

Published on: October 6, 2023

3.0K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.0K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Endocrinology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with alterations in resting-state brain neural activity and cerebral blood flow (CBF).
  • The coupling between neural activity and CBF in T2DM remains poorly understood.

Purpose of the Study:

  • To investigate the alteration of the neurovascular coupling, specifically the ratio of regional homogeneity (ReHo) to CBF (mReHo:mCBF ratio), over 5 years in patients with T2DM.
  • To explore the relationship between the mReHo:mCBF ratio and memory performance in T2DM.

Main Methods:

  • Utilized resting-state functional MRI (rs-fMRI) and arterial spin labeling (ASL) to assess ReHo and CBF in 27 T2DM patients and 36 healthy controls (HCs) over a 5-year interval.
  • Calculated the standardized mReHo:mCBF ratio to represent spontaneous neuronal activity per unit CBF supply.
  • Analyzed intergroup differences and correlations with memory performance.

Main Results:

  • Over 5 years, T2DM patients showed decreased mReHo:mCBF ratios in specific brain regions, notably the left insula.
  • The left insula exhibited a more pronounced decrease in the mReHo:mCBF ratio in T2DM patients compared to HCs.
  • Correlations were observed between the mReHo:mCBF ratio and memory performance in T2DM patients.

Conclusions:

  • T2DM may accelerate neurovascular coupling impairment in the left insula, contributing to memory decline.
  • The mReHo:mCBF ratio shows potential as an imaging biomarker for detecting T2DM-related neurovascular changes and their impact on cognition.