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Related Experiment Video

Updated: Nov 20, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
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Deep Brain Stimulation-Related Surgical Site Infections: A Systematic Review and Meta-Analysis.

Maria Kantzanou1, Stefanos Korfias2, Ioannis Panourias3

  • 1Department of Hygiene, Epidemiology & Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Neuromodulation : Journal of the International Neuromodulation Society
|January 19, 2021
PubMed
Summary

Deep brain stimulation (DBS) surgery has a 5.0% prevalence of surgical site infections (SSIs). Implementing topical vancomycin may reduce SSI risk, but large trials are needed to confirm efficacy.

Keywords:
Deep brain stimulationmeta-analysisprevalencepreventionsurgical site infection

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Area of Science:

  • Neurosurgery
  • Infectious Diseases
  • Medical Device Technology

Background:

  • Deep brain stimulation (DBS) use has increased, raising concerns about adverse effects like surgical site infections (SSIs).
  • SSIs are a significant challenge in neurosurgery, with limited research on DBS-specific complications and risk factors.
  • This study addresses the prevalence and risk factors of SSIs in DBS procedures.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of SSIs following DBS surgery.
  • To identify risk and preventive factors associated with DBS-related SSIs.
  • To assess the impact of interventions like topical vancomycin on SSI rates.

Main Methods:

  • Systematic literature search up to June 2020 with no language restrictions.
  • Meta-analysis of 66 eligible studies including 12,258 participants from 27 countries.
  • Calculation of summary odds ratios (sOR) and 95% confidence intervals (CI) for prevalence and risk factors, assessing heterogeneity and small-study effects.

Main Results:

  • The overall prevalence of SSIs after DBS was 5.0%, with higher rates for dystonia (6.5%), epilepsy (9.5%), Tourette syndrome (5.9%), and OCD (4.5%).
  • Prevalence rates were similar for early- and late-onset hardware infections.
  • Perioperative intra-wound vancomycin use was significantly associated with a reduced risk of SSIs (sOR: 0.26, 95% CI: 0.09-0.74).

Conclusions:

  • The study confirms a high prevalence of SSIs in DBS, particularly for newer indications.
  • Topical vancomycin shows promise as a preventive measure against DBS-related SSIs.
  • Further large clinical trials are necessary to validate the efficacy and safety of preventive strategies.