Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

5.5K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.5K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.7K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exon junction complex and nuclear pore complex components preferentially govern the nuclear export of spliced lncRNAs.

Cell death discovery·2026
Same author

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same author

Age-dependent epigenetic control of flavonoid metabolism underlies chemical defenses in ancient Ginkgo biloba.

The Plant cell·2026
Same author

A feedback mechanism between E3 ligase RNF122 and HIF-1α inhibits aggressive behavior in breast cancer.

Oncogene·2026
Same author

Calcium Phosphate Oligomers as Inorganic Glue for Microcrack Repair in Teeth.

ACS applied materials & interfaces·2026
Same author

Integrated metabolomic and transcriptomic analyses reveal the regulatory role of FcMYB6 in promoting anthocyanin biosynthesis in fig (Ficus carica L.) fruit.

Plant science : an international journal of experimental plant biology·2026

Related Experiment Video

Updated: Nov 20, 2025

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

15.3K

Polydopamine Promotes Dentin Remineralization via Interfacial Control.

Yinan Qu1, Tianyi Gu2, Qiaolin Du1

  • 1Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, P. R. China.

ACS Biomaterials Science & Engineering
|January 19, 2021
PubMed
Summary
This summary is machine-generated.

Polydopamine (PDA) biomolecules successfully repaired dentine, achieving mechanical properties similar to natural dentine. PDA promotes hydroxyapatite (HAP) mineralization within collagen fibrils by reducing interfacial energy, aiding dentine restoration.

Keywords:
biomineralizationcollageninterfacial energynucleationpolydopamine

More Related Videos

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
07:58

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Published on: November 14, 2018

8.5K
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.6K

Related Experiment Videos

Last Updated: Nov 20, 2025

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

15.3K
Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
07:58

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Published on: November 14, 2018

8.5K
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.6K

Area of Science:

  • Biomaterials Science
  • Biomineralization
  • Dental Materials

Background:

  • Mineralization of type I collagen is crucial for hard tissue formation but mechanistically challenging.
  • Understanding the role of biomolecules in collagen mineralization is key for effective tissue repair.
  • Current methods for dentine remineralization lack comprehensive understanding of biomolecular interactions.

Purpose of the Study:

  • To investigate the efficacy of polydopamine (PDA) in promoting dentine remineralization.
  • To elucidate the mechanism by which PDA facilitates intrafibrillar mineralization of collagen.
  • To assess the mechanical properties of PDA-reminalized dentine.

Main Methods:

  • Utilized polydopamine (PDA) as a biomolecule for dentine repair.
  • Analyzed the collagen mineralization process using detailed characterization techniques.
  • Evaluated the mechanical properties of the remineralized dentine and compared them to natural dentine.

Main Results:

  • Successful remineralization of dentine was achieved using PDA.
  • PDA was shown to promote intrafibrillar mineralization of hydroxyapatite (HAP) within collagen fibrils.
  • Reduced interfacial energy between collagen fibrils and amorphous calcium phosphate (ACP) by PDA facilitated HAP nucleation.
  • Remineralized dentine exhibited mechanical properties comparable to natural dentine.

Conclusions:

  • Polydopamine (PDA) is an effective biomolecule for promoting intrafibrillar mineralization in dentine.
  • Controlling interfacial energy is critical for successful dentine remineralization.
  • This study provides significant insights into biomolecule-mediated collagen mineralization and its clinical applications in dentine restoration.