Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoglobulin κ drives liver regeneration by stabilizing MYLK to maintain cytoskeletal integrity and promote hepatocyte proliferation.

Journal of translational internal medicine·2026
Same author

Nano-enabled spatially selective protein degradation modulates lactate metabolism to potentiate antitumor immunity in liver cancer.

Nature nanotechnology·2026
Same author

Synthetic biology-driven bioinspired delivery systems for RNA therapeutics in neural repair.

Neural regeneration research·2026
Same author

ICAM-1 promotes T cell glycolytic reprogramming and tumor infiltration to drive 18F-FDG PET flares following radiotherapy.

Protein & cell·2025
Same author

Zwitterionic Supramolecular Nanoassemblies With siRNA and Simvastatin as "Nanoscavenger" for Synergistic Atherosclerosis Treatment.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

A Nanoradiosensitizer Potentiates Tumor Radiotherapy through JFK Inhibition and Hypoxia Alleviation.

Nano letters·2025

Related Experiment Video

Updated: Nov 20, 2025

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

1.0K

Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System.

Zhiguo Lu1,2, Tianlu Zhang1,2, Xiangyu Wang1

  • 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.

ACS Biomaterials Science & Engineering
|January 19, 2021
PubMed
Summary

Zwitterionic polymer nanoparticles deliver linalool for improved central nervous system regulation. This controlled release system enhances aromatherapy for conditions like depression and anxiety.

Keywords:
adhesion of fragranceencapsulation of fragranceregulation of central nervous systemsustained and pH-sensitive release of fragrancezwitterionic polymer-based nanoparticles

More Related Videos

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

7.7K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.2K

Related Experiment Videos

Last Updated: Nov 20, 2025

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

1.0K
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

7.7K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.2K

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Polymer Chemistry

Background:

  • Aromatherapy is utilized for central nervous system (CNS) disorders, but rapid aroma release limits efficacy.
  • Developing controlled release systems is crucial for enhancing therapeutic effects of aromatherapy.

Purpose of the Study:

  • To create zwitterionic polymer-based nanoparticles encapsulating linalool for sustained CNS regulation.
  • To investigate the impact of nanoparticle properties on linalool encapsulation, adhesion, and release.
  • To evaluate the behavioral and molecular mechanisms of nanoparticle-mediated CNS regulation.

Main Methods:

  • Fabrication of zwitterionic polymer nanoparticles encapsulating linalool.
  • Modification of nanoparticles for electrostatic adhesion to silk.
  • Analysis of polymerization degree, polymer structure, and zeta potential effects on release kinetics.
  • Open field tests for behavioral assessment of CNS regulation.
  • Measurement of neurotransmitter levels (dopamine, acetylcholine, GABA) for molecular mechanism elucidation.

Main Results:

  • Optimal encapsulation, adhesion, and release profiles achieved with specific hydrophilic (20) and hydrophobic (5) block polymerization degrees.
  • Demonstrated sustainable and controlled release of linalool from nanoparticles.
  • Nanoparticles modulated CNS activity at both behavioral (open field tests) and molecular (neurotransmitter levels) levels.

Conclusions:

  • Zwitterionic polymer nanoparticles offer a promising platform for controlled linalool delivery in aromatherapy.
  • The study elucidates the structure-property relationships governing nanoparticle performance.
  • Findings provide insights into the mechanisms underlying nanoparticle-mediated regulation of the central nervous system.