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Updated: Nov 20, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
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Tofu-Incorporated Hydrogels for Potential Bone Regeneration.

Keqing Huang1,2, Zhipeng Gu3,2, Jun Wu1,2

  • 1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China.

ACS Biomaterials Science & Engineering
|January 19, 2021
PubMed
Summary

This study developed tofu-incorporated gelatin methacrylate (GelMa) hydrogels for bone regeneration. These novel hydrogels show promise for tissue engineering due to their biocompatibility and ability to promote bone growth.

Keywords:
bone regenerationgelatin methacrylate (GelMa)hydrogelstofu

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Food-derived materials offer advantages like biosafety and availability for tissue engineering.
  • Gelatin methacrylate (GelMa) is a versatile biomaterial for hydrogel fabrication.
  • Tofu, a food-derived material, was explored for its potential in bone regeneration applications.

Purpose of the Study:

  • To fabricate and characterize tofu-incorporated GelMa hydrogels.
  • To evaluate the potential of these hydrogels for bone regeneration.
  • To assess the cytocompatibility, mechanical properties, and bioactivity of the developed hydrogels.

Main Methods:

  • Fabrication of tofu-incorporated GelMa hydrogels.
  • Assessment of hydrogel architecture, mechanical performance, and cytocompatibility.
  • In vivo evaluation of bone regeneration in a 2-month implantation study.

Main Results:

  • Tofu/GelMa hydrogels exhibited a porous structure, good mechanical properties, and cytocompatibility.
  • Minimal inflammation was observed with tofu/GelMa hydrogels.
  • Tofu incorporation promoted osteogenesis and immune-related cytokine secretion, enhancing bone regeneration.

Conclusions:

  • Tofu/GelMa hydrogels demonstrate significant potential for bone regeneration.
  • These hydrogels offer a low-cost, bioactive solution for tissue engineering.
  • The developed material shows excellent cytocompatibility and bioactivity for regenerative applications.