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Related Experiment Video

Updated: Nov 20, 2025

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Microfluidic Silk Fibers with Aligned Hierarchical Microstructures.

Siyuan Li1,2, Yingjie Hang2, Zhaozhao Ding1

  • 1Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi 214041, China.

ACS Biomaterials Science & Engineering
|January 19, 2021
PubMed
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Researchers created aligned, hierarchical silk fibers using bioinspired microfluidic spinning. These advanced biomaterials mimic natural tissue structures, enhancing cell behavior for tissue regeneration applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • The extracellular matrix (ECM) provides critical niches regulating cell behavior.
  • Recreating hierarchical ECM structures in vitro remains a significant challenge for tissue regeneration.
  • Silk fibers offer a promising biomaterial platform due to their biocompatibility and tunable properties.

Purpose of the Study:

  • To develop regenerated silk fibers with aligned nano- to micro-hierarchical structures.
  • To mimic the native silk gland's hierarchical organization for enhanced biomaterial design.
  • To evaluate the mechanical properties and bioactivity of the fabricated silk fibers.

Main Methods:

  • Integration of "bottom-up" and "top-down" strategies for fiber fabrication.
Keywords:
hierarchical structuremicrofluidicnanofibersnichesilk

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  • Dispersion of silk nanofibers (SNF) in formic acid.
  • Bioinspired microfluidic spinning mimicking native silk gland geometry.

    • Main Results:

    • Fabricated fibers exhibited aligned hierarchical structures superior to traditional methods.
    • Achieved enhanced mechanical properties in the regenerated silk fibers.
    • Demonstrated controlled cell proliferation, migration, and aggregate orientation via Raman spectroscopy.

    Conclusions:

    • The bioinspired microfluidic approach successfully generated aligned hierarchical silk fibers.
    • These novel silk fibers possess superior mechanical properties and bioactivity.
    • The developed bioactive silk fiber materials show significant potential for diverse cell and tissue regeneration applications.