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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
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Maternal and Fetal Outcomes in Systemic Lupus Erythematosus Pregnancies
Yih Jia Poh1, Irene Yuen Lin Yii, Lim Hee Goh
1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.
Annals of the Academy of Medicine, Singapore
|January 19, 2021
Summary
Pregnancies with systemic lupus erythematosus (SLE) have high rates of adverse fetal and maternal outcomes, including preterm birth and miscarriages. Hydroxychloroquine and anti-Ro antibody positivity may reduce preterm delivery risk in SLE pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect pregnancy.
- Understanding maternal and fetal outcomes in SLE pregnancies is crucial for clinical management.
Purpose of the Study:
- To describe maternal and fetal outcomes in pregnancies complicated by SLE.
- To identify potential factors influencing outcomes in SLE pregnancies.
Main Methods:
- A retrospective cohort study was conducted at a tertiary referral center.
- Data from 75 SLE pregnancies between 2000 and 2016 were analyzed for adverse outcomes.
Main Results:
- Most SLE pregnancies resulted in live births (74.7%), but 53.3% experienced adverse fetal outcomes.
- Preterm delivery (33.9%), miscarriages (20%), and fetal growth restriction (17.3%) were common.
- SLE flares occurred in 33% of pregnancies; antiphospholipid syndrome was associated with higher flare and adverse fetal outcome rates.
Conclusions:
- SLE pregnancies, even with quiescent disease, are linked to significant rates of adverse maternal and fetal outcomes.
- Anti-Ro (SS-A) antibody positivity and hydroxychloroquine use may decrease the risk of preterm delivery.
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