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Spinal Malignant Peripheral Nerve Sheath Tumours in Nigerians
T A Oyemolade1, A A Adeolu2, A O Malomo2
1Department of Neurological Surgery,University College Hospital, Ibadan, Nigeria.
West African Journal of Medicine
|January 19, 2021
Summary
Spinal Malignant Peripheral Nerve Sheath Tumours (MPNSTs) are rare and aggressive. This study in a resource-limited setting found high-grade tumors with poor outcomes, highlighting the need for better management strategies.
Area of Science:
- Neuro-oncology
- Surgical Oncology
- Rare Tumors
Background:
- Spinal Malignant Peripheral Nerve Sheath Tumours (MPNSTs) are exceptionally rare and aggressive neoplasms.
- Limited data exists on MPNSTs in Sub-Saharan Africa, particularly in resource-limited settings.
Purpose of the Study:
- To investigate the clinical characteristics and management outcomes of spinal MPNSTs.
- To evaluate the effectiveness of treatment strategies in a resource-constrained environment.
Main Methods:
- Retrospective analysis of patient records for spinal MPNSTs treated between 2004 and 2018.
- Data collection included patient demographics, tumor location, clinical presentation, surgical approach, and outcomes.
Main Results:
- Four patients (27-53 years) with spinal MPNSTs were identified.
- Common symptoms included back pain, limb weakness, sensory deficits, and sphincteric dysfunction.
- High-grade tumors were prevalent (75%), with aggressive disease courses and poor survival, with two patients deceased within 6 months.
Conclusions:
- Spinal MPNSTs are rare, aggressive tumors with a poor prognosis in this resource-limited setting.
- Effective management strategies are crucial due to the aggressive nature and limited treatment options.
