Related Experiment Video
Updated: Nov 20, 2025
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Progression of aural plaques to squamous cell carcinoma in a horse
Jeanine Peters-Kennedy1, Christian E Lange2,3, Kyla Ortved4
1Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Background:
Aural plaques are associated with and thought to be caused by one or more Equus caballus papillomaviruses (EcPV). Aural plaques have not previously been reported to be associated with squamous cell carcinoma (SCC).
Hypothesis/Objectives:
To describe a horse with aural plaques and squamous cell carcinoma (SCC) on the right pinna.
Animals:
A 28-year-old thoroughbred gelding presented for multiple plaques and a mass on the right pinna.
Methods And Materials:
Pinnal resection, histopathological investigation, multiple conventional PCRs for papillomavirus DNA and Sanger sequencing were performed.
Results:
Multiple, raised, pale tan, fronded plaques covered 60% of the concave surface of the right pinna. Focally these plaques coalesced into an exophytic ulcerated mass near the base of the pinna. Multiple aural plaques and a SCC were diagnosed histopathologically. EcPV4 was detected via PCR in a sample of the SCC.
Conclusions And Clinical Importance:
This report demonstrates the possibility of malignant transformation from aural plaques to SCC on the pinna of a horse. To the best of the authors' knowledge, this is the first report of EcPV4 associated with SCC.
More Related Videos
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
06:36Nerve Stimulator-guided Injection of Autologous Stem Cells Near the Equine Left Recurrent Laryngeal Nerve
Published on: September 26, 2018
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:30Atherosclerosis I: Introduction
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:15Auditory Pathway
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...