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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Cardiovascular disease in children with chronic kidney disease

Anne M Kouri1, Michelle N Rheault

  • 1University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.

Current Opinion in Nephrology and Hypertension
|January 19, 2021
PubMed

Insights

Cardiovascular disease (CVD) is a major concern for children with chronic kidney disease (CKD). Emerging research highlights modifiable risk factors like hypertension and obesity, emphasizing the need for further investigation into CVD outcomes in this vulnerable group.

Area of Science:

  • Pediatric Nephrology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in children with chronic kidney disease (CKD).
  • The etiology of CVD in pediatric CKD is complex and multifactorial.
  • Recent studies offer new insights into CVD prevalence and risk factors in this population.

Purpose of the Study:

  • To review current knowledge on the prevalence and risk factors of CVD in children with CKD.
  • To synthesize emerging data on CVD in pediatric CKD.
  • To highlight areas for future research.

Main Methods:

  • Review of recent longitudinal cohort studies.
  • Analysis of data on prevalence and risk factors for CVD.
  • Synthesis of findings on hypertension, obesity, dyslipidemia, and bone mineral disease.

Main Results:

  • Hypertension, including masked and isolated nocturnal hypertension, is linked to CVD markers.
  • Obesity and adiposity, assessed by waist-to-height ratio and fat-free to fat tissue ratio, increase CVD risk.
  • Dyslipidemia is common, with ongoing research into its relationship with bone mineral disease and hyperparathyroidism.

Conclusions:

  • Children with CKD possess multiple, potentially modifiable CVD risk factors.
  • Further research into CVD outcomes in pediatric CKD is essential.
  • Understanding these risk factors is crucial for improving long-term health in children with CKD.
Abstract

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