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Egg-White-/Eggshell-Based Biomimetic Hybrid Hydrogels for Bone Regeneration.
Keqing Huang1,2, Jingyi Hou3, Zhipeng Gu1,2
1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China.
ACS Biomaterials Science & Engineering
|January 19, 2021
Summary
Egg white and eggshell biomimetic hydrogels show promise for bone tissue engineering. These low-cost scaffolds promote cell growth and osteogenic differentiation, offering a new avenue for bone regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bone defects pose significant challenges in regenerative medicine.
- Developing effective biomimetic scaffolds is crucial for bone tissue engineering.
- Novel, cost-effective materials are needed to enhance bone regeneration.
Purpose of the Study:
- To investigate the potential of egg white (EW)-/eggshell (ES)-based hybrid hydrogels for bone regeneration.
- To evaluate the biomimetic properties and bioactivity of EW/ES hydrogels.
- To assess the suitability of these hydrogels as scaffolds in bone tissue engineering.
Main Methods:
- Fabrication of photopolymerized biomimetic hybrid hydrogels using egg white and eggshell.
- Characterization of hydrogel porous structures and mechanical properties.
- Evaluation of cytocompatibility and effects on macrophage behavior.
- Assessment of osteogenic differentiation of human dental pulp stem cells.
Main Results:
- EW/ES hybrid hydrogels exhibited porous structures supporting cell growth.
- Eggshell addition improved mechanical performance and maintained good cytocompatibility.
- The hydrogels modulated macrophage responses and promoted osteogenic differentiation.
- Biomimetic hybrid scaffolds demonstrated good bioactivity and low cost.
Conclusions:
- Egg white/eggshell hybrid hydrogels are promising biomimetic scaffolds for bone tissue engineering.
- These cost-effective materials offer potential for enhanced bone regeneration.
- The developed hydrogels present a viable option for creating suitable microenvironments in bone defects.
