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Related Experiment Video

Updated: Nov 20, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Comparing Effectiveness Between a Mobile App Program and Traditional Cognitive Behavior Therapy in

Hyunchan Hwang1, Sujin Bae2, Ji Sun Hong1

  • 1Department of Psychiatry, Chung-Ang University Hospital, Seoul, Republic of Korea.

JMIR Mental Health
|January 19, 2021
PubMed
Summary

A new mobile app, OCfree, offers effective cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD), showing comparable symptom reduction to traditional methods and enhanced brain connectivity. This digital CBT program improves anxiety and brain function in OCD patients.

Keywords:
behavior therapycognitivecognitive behavior therapycortico-striato-thalamo-cortical tractexposure and response preventionfunctional connectivitymental illnessobsessive-compulsive disorderprevention

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Digital Health

Background:

  • Digital programs show promise for mental illness treatment, enhancing patient motivation and learning.
  • Exposure and response prevention-inspired serious games have been used for obsessive-compulsive disorder (OCD) treatment.

Purpose of the Study:

  • To evaluate if mobile cognitive behavior therapy (CBT) is as effective as traditional offline CBT for OCD.
  • To investigate if mobile CBT efficacy for OCD correlates with increased brain activity in the cortico-striato-thalamo-cortical (CSTC) tract.

Main Methods:

  • A digital CBT program (OCfree) with educational sessions, quests, and games was used.
  • 27 drug-naïve OCD patients participated: 15 in offline CBT and 12 in OCfree CBT groups.
  • Clinical symptoms and brain function were analyzed over a 6-week intervention period.

Main Results:

  • No significant difference in OCD and depressive symptom changes between groups.
  • The OCfree group demonstrated greater improvement in anxiety symptoms than the offline CBT group.
  • Both treatments increased CSTC tract functional connectivity; OCfree showed greater changes in the thalamus and insula.

Conclusions:

  • OCfree is an effective app for treating drug-naïve OCD patients.
  • OCfree's therapeutic effects are linked to enhanced CSTC tract brain connectivity.
  • Multisensory stimulation in OCfree boosts activity in the thalamus and insula for OCD patients.