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Related Concept Videos

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Updated: Nov 20, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Diabetes, Lipids, and CV Risk.

Jan Škrha1

  • 13rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. jan.skrha2@LF1.cuni.cz.

Current Atherosclerosis Reports
|January 19, 2021
PubMed
Summary

This review summarizes treatments for diabetic dyslipidemia, a key factor in cardiovascular disease. Novel therapies targeting lipid and glucose metabolism significantly reduce cardiovascular risk beyond glucose control alone.

Keywords:
AtherosclerosisCardiovascular riskDiabetesPrevention

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus is frequently linked to diabetic dyslipidemia.
  • Hyperglycemia and dyslipidemia are major contributors to atherosclerosis, a primary cause of cardiovascular disease (CVD).

Purpose of the Study:

  • To review current therapeutic strategies for reducing cardiovascular risk in patients with diabetes.
  • To highlight advancements in managing dyslipidemia and hyperglycemia for improved CVD outcomes.

Main Methods:

  • Literature review of recent advancements in pharmacologic treatments for diabetic dyslipidemia and hyperglycemia.
  • Analysis of studies evaluating cardiovascular benefits of novel therapeutic agents.

Main Results:

  • Novel agents like PCSK9 inhibitors have transformed dyslipidemia management.
  • Modern antihyperglycemic drugs, including SGLT2 inhibitors and GLP-1 receptor agonists, offer significant metabolic and cardiovascular benefits.
  • Effective cardiovascular risk reduction requires a multifactorial approach targeting various pathological disturbances.

Conclusions:

  • Diabetes management is evolving beyond glucose-centric approaches.
  • Pharmacologic interventions targeting lipid and glucose metabolism provide powerful tools for substantial cardiovascular risk reduction in diabetic patients.