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Post-COVID-19 Cholangiopathy: A Novel Entity
Nitzan C Roth1, Angela Kim2, Taisia Vitkovski3
1Division of Hepatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.
The American Journal of Gastroenterology
|January 19, 2021
Summary
Coronavirus disease 2019 (COVID-19) can cause prolonged liver issues. This study identifies a novel severe post-COVID-19 cholangiopathy with potential for long-term liver damage.
Area of Science:
- Hepatology
- Virology
- Critical Care Medicine
Background:
- Liver chemistry abnormalities are common in coronavirus disease 2019 (COVID-19), typically resolving with illness.
- Severe cases of COVID-19 can lead to prolonged and severe cholestasis during the recovery phase.
Observation:
- Three adult patients who experienced critical cardiopulmonary COVID-19 developed prolonged, severe cholestasis.
- Histologic examination revealed features resembling secondary sclerosing cholangitis in the critically ill.
Findings:
- Unique histologic findings included severe cholangiocyte injury and intrahepatic microangiopathy.
- These features suggest direct hepatic injury caused by COVID-19.
Implications:
- The cases represent a novel severe post-COVID-19 cholangiopathy.
- This condition may lead to long-term hepatic morbidity in affected individuals.
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